{"id":5152,"date":"2024-05-13T15:36:00","date_gmt":"2024-05-13T07:36:00","guid":{"rendered":"https:\/\/ai-stack.ai\/?p=5152"},"modified":"2024-12-09T15:27:27","modified_gmt":"2024-12-09T07:27:27","slug":"alphafold-3","status":"publish","type":"post","link":"https:\/\/ai-stack.ai\/zh-hant\/alphafold-3","title":{"rendered":"AlphaFold 3: AI\u751f\u7269\u79d1\u5b78\u5927\u8e8d\u9032"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u751f\u547d\u79d1\u5b78\u7684\u7814\u7a76\u5411\u4f86\u662f\u4eba\u985e\u63a2\u7d22\u81ea\u8eab\u548c\u81ea\u7136\u754c\u5967\u79d8\u7684\u91cd\u8981\u9014\u5f91\u3002\u800c\u5728\u9019\u500b\u904e\u7a0b\u4e2d\uff0c\u6211\u5011\u5e38\u5e38\u6703\u9047\u5230\u5404\u7a2e\u6311\u6230\u548c\u969c\u7919\u3002\u5176\u4e2d\uff0c\u5982\u4f55\u78ba\u5b9a\u751f\u7269\u5927\u5206\u5b50(\u5982\u86cb\u767d\u8cea\u3001DNA\u3001RNA)\u7684\u4e09\u7dad\u7d50\u69cb\uff0c\u4ee5\u53ca\u5b83\u5011\u4e4b\u9593\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4e00\u76f4\u662f\u751f\u7269\u5b78\u5bb6\u5011\u52aa\u529b\u653b\u514b\u7684\u96e3\u984c\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u50b3\u7d71\u7684\u5be6\u9a57\u65b9\u6cd5\uff0c\u5982X\u5c04\u7dda\u6676\u9ad4\u5b78\u548c\u6838\u78c1\u5171\u632f\uff0c\u96d6\u7136\u80fd\u5920\u63d0\u4f9b\u7cbe\u78ba\u7684\u7d50\u69cb\u4fe1\u606f\uff0c\u4f46\u5f80\u5f80\u8017\u6642\u6578\u5e74\uff0c\u6210\u672c\u9ad8\u6602\u3002\u9019\u6975\u5927\u5730\u9650\u5236\u4e86\u6211\u5011\u5c0d\u751f\u547d\u5206\u5b50\u7684\u7814\u7a76\u9032\u5c55\u3002\u7136\u800c\uff0c\u96a8\u8457\u4eba\u5de5\u667a\u6167\u6280\u8853\u7684\u5feb\u901f\u767c\u5c55\uff0c\u9019\u4e00\u5c40\u9762\u6b63\u5728\u88ab\u6539\u5beb\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2020\u5e74\uff0cGoogle DeepMind\u767c\u5e03\u4e86AlphaFold 2\uff0c\u8a72AI\u7cfb\u7d71\u5728\u7b2c14\u5c46\u95dc\u9375\u8a55\u4f30\u86cb\u767d\u8cea\u7d50\u69cb\u9810\u6e2c(CASP14)\u6311\u6230\u4e2d\uff0c\u4ee5\u9060\u8d85\u7b2c\u4e8c\u540d\u7684\u6210\u7e3e\u596a\u51a0\uff0c\u5be6\u73fe\u4e86\u5c0d\u86cb\u767d\u8cea\u647a\u758a\u554f\u984c\u7684\u7a81\u7834\u6027\u89e3\u6c7a\u3002\u800c\u57282024\u5e745\u6708\uff0cDeepMind\u518d\u6b21\u5e36\u4f86\u4e86AlphaFold\u7684\u6700\u65b0\u9032\u5316\u7248\u672c\u2014\u2014AlphaFold 3\uff0c\u5c07\u4eba\u5de5\u667a\u6167\u5728\u751f\u7269\u5b78\u9818\u57df\u7684\u61c9\u7528\u63a8\u5411\u4e86\u4e00\u500b\u65b0\u7684\u9ad8\u5ea6\u3002<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<span class=\"embed-youtube\" style=\"text-align:center; display: block;\"><iframe class=\"youtube-player\" width=\"1300\" height=\"732\" src=\"https:\/\/www.youtube.com\/embed\/9ufplEgtq8w?version=3&#038;rel=1&#038;showsearch=0&#038;showinfo=1&#038;iv_load_policy=1&#038;fs=1&#038;hl=zh-TW&#038;autohide=2&#038;wmode=transparent\" allowfullscreen=\"true\" style=\"border:0;\" sandbox=\"allow-scripts allow-same-origin allow-popups allow-presentation allow-popups-to-escape-sandbox\"><\/iframe><\/span>\n<\/div><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>AlphaFold 3<\/strong><strong>\u7684\u6838\u5fc3\u80fd\u529b<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">AlphaFold 3\u662f\u4e00\u500b\u529f\u80fd\u5f37\u5927\u7684AI\u6a21\u578b\uff0c\u5b83\u4e0d\u50c5\u80fd\u9810\u6e2c\u86cb\u767d\u8cea\u7684\u7d50\u69cb\uff0c\u9084\u80fd\u9810\u6e2c\u5305\u62ecDNA\u3001RNA\u548c\u5c0f\u5206\u5b50(\u5982\u85e5\u7269)\u5728\u5167\u7684\u5404\u7a2e\u751f\u7269\u5206\u5b50\u7684\u7d50\u69cb\uff0c\u4ee5\u53ca\u5b83\u5011\u4e4b\u9593\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u9019\u4f7fAlphaFold 3\u6210\u70ba\u4e86\u4e00\u500b\u6db5\u84cb\u6240\u6709\u751f\u547d\u5206\u5b50\u7684\u901a\u7528\u6a21\u578b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8207\u524d\u4ee3AlphaFold\u76f8\u6bd4\uff0cAlphaFold 3\u5728\u9810\u6e2c\u7cbe\u5ea6\u548c\u9069\u7528\u7bc4\u570d\u4e0a\u90fd\u6709\u4e86\u5de8\u5927\u7684\u63d0\u5347\u3002\u5728\u9810\u6e2c\u85e5\u7269\u6a23\u5c0f\u5206\u5b50\u8207\u86cb\u767d\u8cea\u7d50\u5408\u65b9\u5f0f\u7684PoseBusters\u57fa\u6e96\u6e2c\u8a66\u4e2d\uff0cAlphaFold 3\u6bd4\u73fe\u6709\u6700\u4f73\u65b9\u6cd5\u7684\u9810\u6e2c\u7cbe\u5ea6\u63d0\u9ad8\u4e8650%\uff0c\u6210\u70ba\u9996\u500b\u5728\u8a72\u9805\u4efb\u52d9\u4e0a\u8d85\u8d8a\u7269\u7406\u65b9\u6cd5\u7684AI\u7cfb\u7d71\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">AlphaFold 3\u7684\u5de5\u4f5c\u539f\u7406\u662f\u4ec0\u9ebc?\u5b83\u63a1\u7528\u4e86\u4e00\u7a2e\u7a31\u70ba&#8221;Evoformer&#8221;\u7684\u6df1\u5ea6\u5b78\u7fd2\u67b6\u69cb\uff0c\u901a\u904e\u5c0d\u5927\u91cf\u5df2\u77e5\u7d50\u69cb\u7684\u86cb\u767d\u8cea\u9032\u884c\u8a13\u7df4\uff0c\u5b78\u7fd2\u6c28\u57fa\u9178\u5e8f\u5217\u8207\u86cb\u767d\u8cea\u7d50\u69cb\u4e4b\u9593\u7684\u5c0d\u61c9\u95dc\u4fc2\u3002\u5728\u9810\u6e2c\u65b0\u86cb\u767d\u8cea\u7684\u7d50\u69cb\u6642\uff0cAlphaFold 3\u9996\u5148\u5c0d\u6c28\u57fa\u9178\u5e8f\u5217\u9032\u884c\u8655\u7406\uff0c\u7136\u5f8c\u4f7f\u7528\u985e\u4f3c\u65bc\u64f4\u6563\u6a21\u578b\u7684\u7db2\u8def\uff0c\u5f9e\u4e00\u5718\u539f\u5b50\u96f2\u958b\u59cb\uff0c\u9010\u6b65\u512a\u5316\u548c\u6536\u6582\uff0c\u6700\u7d42\u751f\u6210\u7cbe\u78ba\u7684\u5206\u5b50\u7d50\u69cb\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u9664\u4e86\u7d50\u69cb\u9810\u6e2c\uff0cAlphaFold 3\u9084\u80fd\u5920\u9810\u6e2c\u4e0d\u540c\u5206\u5b50\u4e4b\u9593\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u9019\u5c0d\u65bc\u7406\u89e3\u751f\u7269\u5b78\u529f\u80fd\u81f3\u95dc\u91cd\u8981\uff0c\u56e0\u70ba\u5728\u751f\u547d\u7cfb\u7d71\u4e2d\uff0c\u5206\u5b50\u4e26\u4e0d\u662f\u5b64\u7acb\u5b58\u5728\u7684\uff0c\u5b83\u5011\u901a\u904e\u76f8\u4e92\u4f5c\u7528\u3001\u7d50\u5408\u3001\u8abf\u63a7\uff0c\u5171\u540c\u5b8c\u6210\u5fa9\u96dc\u7684\u751f\u547d\u6d3b\u52d5\u3002\u4f8b\u5982\uff0c\u901a\u904e\u5206\u6790\u86cb\u767d\u8cea\u8207\u86cb\u767d\u8cea\u3001\u86cb\u767d\u8cea\u8207DNA\/RNA\u3001\u86cb\u767d\u8cea\u8207\u5c0f\u5206\u5b50\u7684\u7d50\u5408\u65b9\u5f0f\uff0c\u6211\u5011\u53ef\u4ee5\u66f4\u597d\u5730\u7406\u89e3\u57fa\u56e0\u8868\u9054\u8abf\u63a7\u3001\u7d30\u80de\u4fe1\u865f\u8f49\u5c0e\u3001\u85e5\u7269\u4f5c\u7528\u6a5f\u5236\u7b49\u751f\u7269\u5b78\u904e\u7a0b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7e3d\u7684\u4f86\u8aaa\uff0cAlphaFold 3\u70ba\u751f\u7269\u5b78\u5bb6\u5011\u63d0\u4f9b\u4e86\u4e00\u500b\u524d\u6240\u672a\u6709\u7684\u5f37\u5927\u5de5\u5177\u3002\u501f\u52a9\u8a72\u7cfb\u7d71\uff0c\u7814\u7a76\u4eba\u54e1\u53ea\u9700\u63d0\u4f9b\u5206\u5b50\u7684\u5e8f\u5217\u4fe1\u606f\uff0c\u5c31\u80fd\u5728\u5e7e\u5206\u9418\u5167\u5f97\u5230\u904e\u53bb\u9700\u8981\u6578\u5e74\u5be6\u9a57\u624d\u80fd\u78ba\u5b9a\u7684\u7d50\u69cb\u548c\u76f8\u4e92\u4f5c\u7528\u6578\u64da\u3002\u9019\u5c07\u6975\u5927\u5730\u52a0\u901f\u751f\u7269\u5b78\u7814\u7a76\u7684\u9032\u7a0b\uff0c\u8b93\u6211\u5011\u80fd\u5920\u66f4\u5feb\u3001\u66f4\u9ad8\u6548\u5730\u63ed\u793a\u751f\u547d\u7684\u5967\u79d8\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>AlphaFold 3<\/strong><strong>\u5728\u751f\u7269\u91ab\u85e5\u9818\u57df\u7684\u61c9\u7528<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">AlphaFold 3\u5728\u751f\u7269\u91ab\u85e5\u9818\u57df\u5177\u6709\u5ee3\u6cdb\u7684\u61c9\u7528\u524d\u666f\u3002\u85e5\u7269\u7814\u767c\u662f\u5176\u4e2d\u6700\u70ba\u91cd\u8981\u7684\u65b9\u5411\u4e4b\u4e00\u3002\u958b\u767c\u4e00\u7a2e\u65b0\u85e5\u9700\u8981\u6295\u5165\u5927\u91cf\u7684\u6642\u9593\u548c\u8cc7\u91d1\uff0c\u5176\u4e2d\u5f88\u5927\u4e00\u90e8\u5206\u7528\u65bc\u7be9\u9078\u548c\u512a\u5316\u5148\u5c0e\u5316\u5408\u7269\u3002\u50b3\u7d71\u7684\u85e5\u7269\u7be9\u9078\u65b9\u6cd5\uff0c\u5982\u9ad8\u901a\u91cf\u7be9\u9078\uff0c\u96d6\u7136\u80fd\u5920\u5728\u6d77\u91cf\u5316\u5408\u7269\u5eab\u4e2d\u5c0b\u627e\u5177\u6709\u6d3b\u6027\u7684\u5206\u5b50\uff0c\u4f46\u5f80\u5f80\u5b58\u5728\u5047\u967d\u6027\u7387\u9ad8\u3001\u91dd\u5c0d\u6027\u5dee\u7b49\u554f\u984c\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u800c\u5229\u7528AlphaFold 3\uff0c\u6211\u5011\u53ef\u4ee5\u5f9e\u8a08\u7b97\u6a5f\u4e0a\u6a21\u64ec\u5c0f\u5206\u5b50\u8207\u9776\u86cb\u767d\u7684\u7d50\u5408\uff0c\u5feb\u901f\u9810\u6e2c\u5176\u89aa\u548c\u529b\u548c\u7d50\u5408\u6a21\u5f0f\uff0c\u5f9e\u800c\u5927\u5927\u7e2e\u5c0f\u5019\u9078\u85e5\u7269\u7684\u7bc4\u570d\u3002\u540c\u6642\uff0c\u901a\u904e\u512a\u5316\u85e5\u7269\u5206\u5b50\u8207\u9776\u9ede\u7684\u7d50\u5408\u65b9\u5f0f\uff0c\u9084\u53ef\u4ee5\u63d0\u9ad8\u85e5\u7269\u7684\u9078\u64c7\u6027\u548c\u6709\u6548\u6027\uff0c\u964d\u4f4e\u6bd2\u526f\u4f5c\u7528\u3002\u9019\u5c07\u986f\u8457\u52a0\u5feb\u65b0\u85e5\u7814\u767c\u7684\u9032\u7a0b\uff0c\u7e2e\u77ed\u65b0\u85e5\u4e0a\u5e02\u7684\u6642\u9593\uff0c\u9020\u798f\u5ee3\u5927\u60a3\u8005\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8c37\u6b4c\u65d7\u4e0b\u5c08\u6ce8\u65bcAI\u9a45\u52d5\u85e5\u7269\u767c\u73fe\u7684\u5b50\u516c\u53f8Isomorphic Labs\uff0c\u6b63\u5728\u5c07AlphaFold 3\u61c9\u7528\u65bc\u591a\u500b\u85e5\u7269\u7814\u767c\u9805\u76ee\u3002\u901a\u904e\u6574\u5408AlphaFold 3\u8207\u8a72\u516c\u53f8\u81ea\u4e3b\u7814\u767c\u7684\u5176\u4ed6AI\u6a21\u578b\uff0cIsomorphic Labs\u6b63\u5728\u63a2\u7d22\u5168\u65b0\u7684\u85e5\u7269\u8a2d\u8a08\u65b9\u6cd5\uff0c\u6311\u6230\u904e\u53bb\u96e3\u4ee5\u99d5\u99ad\u7684\u85e5\u7269\u9776\u9ede\uff0c\u70ba\u958b\u767c\u7a81\u7834\u6027\u7642\u6cd5\u92ea\u5e73\u9053\u8def\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u9664\u4e86\u85e5\u7269\u7814\u767c\uff0cAlphaFold 3\u5728\u75be\u75c5\u8a3a\u65b7\u548c\u7cbe\u6e96\u91ab\u7642\u65b9\u9762\u4e5f\u6709\u8457\u5de8\u5927\u7684\u61c9\u7528\u6f5b\u529b\u3002\u8a31\u591a\u75be\u75c5\u7684\u767c\u751f\u8207\u86cb\u767d\u8cea\u7684\u7d50\u69cb\u7570\u5e38\u548c\u529f\u80fd\u5931\u8abf\u5bc6\u5207\u76f8\u95dc\u3002\u4f8b\u5982\uff0c\u963f\u723e\u8328\u6d77\u9ed8\u75c7\u8207tau\u86cb\u767d\u7684\u7570\u5e38\u805a\u96c6\u6709\u95dc;\u67d0\u4e9b\u764c\u75c7\u7684\u767c\u751f\u6d89\u53ca\u81f4\u764c\u57fa\u56e0\u7de8\u78bc\u86cb\u767d\u7684\u7a81\u8b8a\u548c\u5931\u63a7\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5229\u7528AlphaFold 3\uff0c\u6211\u5011\u53ef\u4ee5\u5206\u6790\u9019\u4e9b\u75be\u75c5\u76f8\u95dc\u86cb\u767d\u7684\u7d50\u69cb\u7279\u9ede\uff0c\u9810\u6e2c\u7a81\u8b8a\u6216\u4fee\u98fe\u5c0d\u5176\u529f\u80fd\u7684\u5f71\u97ff\uff0c\u9032\u800c\u767c\u5c55\u51fa\u66f4\u654f\u611f\u3001\u66f4\u7279\u7570\u7684\u8a3a\u65b7\u65b9\u6cd5\u3002\u540c\u6642\uff0cAlphaFold 3\u9084\u53ef\u4ee5\u5e6b\u52a9\u6211\u5011\u8a2d\u8a08\u91dd\u5c0d\u6027\u66f4\u5f37\u3001\u526f\u4f5c\u7528\u66f4\u5c0f\u7684\u6cbb\u7642\u65b9\u6848\uff0c\u5be6\u73fe\u5c0d\u75be\u75c5\u7684\u7cbe\u51c6\u6cbb\u7642\uff0c\u63d0\u9ad8\u60a3\u8005\u7684\u751f\u5b58\u8cea\u91cf\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>AlphaFold 3<\/strong><strong>\u63a8\u52d5\u57fa\u790e\u751f\u7269\u5b78\u7814\u7a76<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">AlphaFold 3\u7684\u5f71\u97ff\u4e0d\u50c5\u9650\u65bc\u751f\u7269\u91ab\u85e5\u9818\u57df\uff0c\u5728\u57fa\u790e\u751f\u7269\u5b78\u7814\u7a76\u4e2d\uff0c\u5b83\u540c\u6a23\u5927\u653e\u7570\u5f69\u3002\u4e86\u89e3\u86cb\u767d\u8cea\u7684\u7d50\u69cb\u548c\u529f\u80fd\u4e00\u76f4\u662f\u751f\u7269\u5b78\u7684\u6838\u5fc3\u554f\u984c\u4e4b\u4e00\u3002\u86cb\u767d\u8cea\u53c3\u8207\u4e86\u5e7e\u4e4e\u6240\u6709\u7684\u751f\u547d\u6d3b\u52d5\uff0c\u4f8b\u5982\u9176\u50ac\u5316\u3001\u4fe1\u865f\u8f49\u5c0e\u3001\u514d\u75ab\u61c9\u7b54\u3001\u7d30\u80de\u9aa8\u67b6\u69cb\u5efa\u7b49\u3002\u800c\u86cb\u767d\u8cea\u7684\u529f\u80fd\uff0c\u5f88\u5927\u7a0b\u5ea6\u4e0a\u53d6\u6c7a\u65bc\u5176\u7368\u7279\u7684\u4e09\u7dad\u7d50\u69cb\u3002\u56e0\u6b64\uff0c\u89e3\u6790\u86cb\u767d\u8cea\u7d50\u69cb\uff0c\u662f\u7406\u89e3\u5176\u751f\u7269\u5b78\u529f\u80fd\u7684\u57fa\u790e\u3002<\/p>\n\n\n\n<p 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